Three-dimensional quantitative structure-activity relationship analyses of RGD mimetics as fibrinogen receptor antagonists

M Miyashita; M Akamatsu; Y Hayashi; T Ueno

doi:10.1016/s0960-894x(00)00113-x

Three-dimensional quantitative structure-activity relationship analyses of RGD mimetics as fibrinogen receptor antagonists

Bioorg Med Chem Lett. 2000 May 1;10(9):859-63. doi: 10.1016/s0960-894x(00)00113-x.

Authors

M Miyashita¹, M Akamatsu, Y Hayashi, T Ueno

Affiliation

¹ Graduate School of Agriculture, Kyoto University, Japan.

PMID: 10853647
DOI: 10.1016/s0960-894x(00)00113-x

Abstract

In order to better understand the structural requirements of fibrinogen receptor antagonists, variations in the platelet aggregation inhibitory activity of a series of RGD mimetics were examined using techniques for the analysis of three-dimensional quantitative structure activity relationship, such as CoMFA.

MeSH terms

Chemical Phenomena
Chemistry, Physical
Humans
In Vitro Techniques
Models, Molecular
Molecular Conformation
Oligopeptides / chemical synthesis
Oligopeptides / chemistry*
Oligopeptides / pharmacology
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / chemical synthesis
Platelet Aggregation Inhibitors / pharmacology
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
Receptors, Immunologic / antagonists & inhibitors*
Stereoisomerism
Structure-Activity Relationship

Substances

Oligopeptides
Platelet Aggregation Inhibitors
Platelet Glycoprotein GPIIb-IIIa Complex
Receptors, Immunologic
arginyl-glycyl-aspartic acid